செவ்வாய், 20 ஜனவரி, 2015

CT Scan vs. MRI

CT Scan vs. MRI

 
 
MRI
A CT Scan (or CAT Scan) is best suited for viewing bone injuries, diagnosing lung and chest problems, and detecting cancers. An MRI is suited for examining soft tissue in ligament and tendon injuries, spinal cord injuries, brain tumors, etc. CT scans are widely used in emergency rooms because the scan takes fewer than 5 minutes. An MRI, on the other hand, can take up to 30 minutes.
An MRI typically costs more than a CT scan. One advantage of an MRI is that it does not use radiation while CAT scans do. This radiation is harmful if there is repeated exposure.

Comparison chart


CT Scan

MRI

Radiation exposure The effective radiation dose from CT ranges from 2 to 10 mSv, which is about the same as the average person receives from background radiation in 3 to 5 years. Usually, CT is not recommended for pregnant women or children unless absolutely necessary. None. MRI machines do not emit ionizing radiation.
Time taken for complete scan Usually completed within 5 minutes. Actual scan time usually less than 30 seconds. Therefore, CT is less sensitive to patient movement than MRI. Depending on what the MRI is looking for, and where it is needing to look, the scan may be quick (finished in 10-15 minutes) or may take a long time (2 hours).
Cost CT Scan costs range from $1,200 to $3,200; they usually cost less than MRIs (about half the price of MRI). MRI costs range from $1,200 to $4,000 (with contrast), which is usually more expensive than CT scans and X-rays, and most examining methods.
Acronym for Computed (Axial) Tomography Magnetic Resonance Imaging.
Effects on the body Despite being small, CT can pose the risk of irradiation. Painless, noninvasive. No biological hazards have been reported with the use of MRI. However, some may be allergic to the contrast dye, which is also inappropriate for those suffering from kidney or liver disorders.
Ability to change the imaging plane without moving the patient With capability of MDCT, isotropic imaging is possible. After helical scan with Multiplanar Reformation function, an operator can construct any plane. MRI machines can produce images in any plane. Plus, 3D isotropic imaging also can also produce Multiplanar Reformation.
Application Suited for bone injuries, Lung and Chest imaging, cancer detection. Widely used on Emergency Room patients. Suited for Soft tissue evaluation, e.g., ligament and tendon injury, spinal cord injury, brain tumors, etc.
Details of bony structures Provides good details about bony structures Less detailed compared to X-ray
Details of soft tissues A major advantage of CT is that it is able to image bone, soft tissue and blood vessels all at the same time. Much higher soft tissue detail as compare to CT scan.
Principle used for imaging Uses X-rays for imaging Uses large external field, RF pulse and 3 different gradient fields
Scope of application CT can outline bone inside the body very accurately. MRI is more versatile than the X-Ray and is used to examine a large variety of medical conditions.
Intravenous Contrast Agent Non-ionic iodinated agents covalently bind the iodine and have fewer side effects. Allergic reaction is rare but more common than MRI contrast. Risk of contrast induced nephropathy (especially in renal insufficiency (GFR<60), diabetes & dehydration). Very rare allergic reaction. Risk of reaction in those who have or have a history of kidney or liver disorders.
Comfort level for patient Seldom creates claustrophobia Anxiety, especially anxiety caused by claustrophobia, is common, as is tiredness or annoyance over having to stay still on a hard table for a long period of time.
Principle X-ray attenuation is detected by detector & DAS system, followed by math. model (back projection model) to calculate the value of pixelism that becomes a image. Body tissues that contain hydrogen atoms (e.g. in water) are made to emit a radio signal which are detected by the scanner. Search for "magnetic resonance" for physics details.
History The first commercially viable CT scanner was invented by Sir Godfrey Hounsfield in Hayes, United Kingdom. First patient's brain-scan was done on 1 October 1971. First commercial MRI was available in 1981, with significant increase in MRI resolution and choice of imaging sequences over time.
Image specifics Good soft tissue differentiation especially with intravenous contrast. Higher imaging resolution and less motion artifact due to fast imaging speed. Demonstrates subtle differences between different kinds of soft tissues.
Limitation for Scanning patients Patients with metal implants can get CT scan. A person who is very large (e.g. over 450 lb) may not fit into the opening of a conventional CT scanner or may be over the weight limit for the moving table. Patients with Cardiac Pacemakers, tattoos and metal implants are contraindicated due to possible injury to patient or image distortion (artifact). Patient over 350 lb may be over table's weight limit. Any ferromagnetic object may cause trauma/burn.

How the scans work

An MRI of the left knee.
An MRI of the left knee.

How MRIs work

Using a very powerful magnet and pulsing radio waves, the detection coils in the MRI scanner read the energy produced by water molecules as they realign themselves after each RF alignment pulse. The collected data is reconstructed into a two-dimensional illustration through any axis of the body. Bones are virtually void of water and therefore do not generate any image data. This leaves a black area in the images. MRI scanners are best suited for imaging soft tissue.
The CT scan of a person's torso.
The CT scan of a person's torso.

How a CT Scan works

CT, Computerized Axial Tomography, uses x-rays to generate images of the body, including bone. In the CT scanner the x-ray tube, (source) rotates around the patient laying on the table. On the opposite side of the patient from the tube is the x-ray detector. This detector receives the beam that makes it through the patient. The beam is sampled via some 764 channels, (approximate number of channels). The signal received by each channel is digitized to a 16 bit value and sent to the reconstruction processor. Measurements are taken about 1000 times per second. Scan rotations are usually 1 to 2 seconds long. Each view/channel chunk of scan data is compared to calibration scan data of air, water and polyethylene (soft plastic), previously acquired in the exact same relative location. The comparisons allow the image pixels to have a known value for a particular substance in the body regardless of differences in patient size and exposure factors. The more samples or views, the better the picture.
The following video explains how the different types of scans work — Ultrasound, CT scan, MRI and PET scan.

Pros and Cons

In this ABC News video, Paul Christo, M.D. at Johns Hopkins explains the use of MRI or CT scans for diagnosing problems related to the spine.


Advantages of MRI over CAT Scan

  • A CAT scan uses X rays to build up a picture. MRI uses a magnetic field to do the same and has no known side effects related to radiation exposure.
  • MRI gives higher detail in soft tissues.
  • One of the greatest advantages of MRI is the ability to change the contrast of the images. Small changes in radio waves and magnetic fields can completely change the contrast of the image. Different contrast settings will highlight different types of tissue.
  • Another advantage of MRI is the ability to change the imaging plane without moving the patient. Most MRI machines can produce images in any plane.
  • Contrast agents are also used in MRI but they are not made of iodine. There are fewer documented cases of reactions to MRI contrast and it is considered to be safer than X-ray dyes.
  • For purposes of tumor detection and identification, MRI is generally superior. However, CT usually is more widely available, faster, much less expensive, and may be less likely to require the person to be sedated or anesthetized.
  • CT may be enhanced by use of contrast agents containing elements of a higher atomic number (iodine, barium) than the surrounding flesh. Contrast agents for MRI are those which have paramagnetic properties. One example is gadolinium. Iodine use may be associated with allergic reactions.

CT scans and cancer

The radiation from CT scans is harmful and repeated scans can even cause cancer. In a February 2014 article, the New York Times reported that
The radiation doses of CT scans (a series of X-ray images from multiple angles) are 100 to 1,000 times higher than conventional X-rays.
A single CT scan exposes a patient to the amount of radiation that epidemiologic evidence shows can be cancer-causing. The risks have been demonstrated directly in two large clinical studies in Britain and Australia. In the British study, children exposed to multiple CT scans were found to be three times more likely to develop leukemia and brain cancer. In a 2011 report sponsored by Susan G. Komen, the Institute of Medicine concluded that radiation from medical imaging, and hormone therapy, the use of which has substantially declined in the last decade, were the leading environmental causes of breast cancer, and advised that women reduce their exposure to unnecessary CT scans.

Advantages of CT Scan over MRI

  • CT is very good for imaging bone structures.
  • Some patients who have received certain types of surgical clips, metallic fragments, cardiac monitors or pacemakers cannot receive an MRI.
  • The time taken for total testing is shorter than taken by MRI.
  • MRI cannot be done on patients who are claustrophobic as the patient has to remain inside the noisy machine for about 20-45 minutes.
  • CT scan is cheaper than an MRI. A CT scan costs $1,200 to $3,200 while an MRI can cost up to $4,000.

Cost of Machines

Not surprisingly, there are various CT scanners available and there is a large variation in price depending upon the features and brand. This is a good pricing guide for CT scan machines. A vanilla 4-slice CT scanner costs $85,000 to $150,000. A 16-slice scanner costs $145,000 to $225,000 and the top-of-the-line 64-slice CTs can cost up to $450,000. The machines may typically need annual maintenance, which can cost tens of thousands of dollars.
MRI machines are available in 1.5 T and 3 T (T stands for Tesla) models. 3T models are more expensive but offer higher image quality and shorter scanning times. 1.5 T MRI scanners start at around $1 million and 3T models are 50% more expensive. Manufacturers may include accessories, such as a workstation to view images and contrast injectors, in their quotes for MRI scanners. (For a guide on MRI scanners, see here.)

References

Analog vs. Digital

Analog vs. Digital


Analog and digital signals are used to transmit information, usually through electric signals. In both these technologies, the information, such as any audio or video, is transformed into electric signals. The difference between analog and digital technologies is that in analog technology, information is translated into electric pulses of varying amplitude. In digital technology, translation of information is into binary format (zero or one) where each bit is representative of two distinct amplitudes.

Definitions of Analog vs. Digital signals

An Analog signal is any continuous signal for which the time varying feature (variable) of the signal is a representation of some other time varying quantity, i.e., analogous to another time varying signal. It differs from a digital signal in terms of small fluctuations in the signal which are meaningful.
A digital signal uses discrete (discontinuous) values. By contrast, non-digital (or analog) systems use a continuous range of values to represent information. Although digital representations are discrete, the information represented can be either discrete, such as numbers or letters, or continuous, such as sounds, images, and other measurements of continuous systems.

Properties of Digital vs Analog signals

Digital information has certain properties that distinguish it from analog communication methods. These include
  • Synchronization – digital communication uses specific synchronization sequences for determining synchronization.
  • Language – digital communications requires a language which should be possessed by both sender and receiver and should specify meaning of symbol sequences.
  • Errors – disturbances in analog communication causes errors in actual intended communication but disturbances in digital communication does not cause errors enabling error free communication. Errors should be able to substitute, insert or delete symbols to be expressed.
  • Copying – analog communication copies are quality wise not as good as their originals while due to error free digital communication, copies can be made indefinitely.
  • Granularity – for a continuously variable analog value to be represented in digital form there occur quantization error which is difference in actual analog value and digital representation and this property of digital communication is known as granularity.

Differences in Usage in Equipment

Many devices come with built in translation facilities from analog to digital. Microphones and speaker are perfect examples of analog devices. Analog technology is cheaper but there is a limitation of size of data that can be transmitted at a given time.
Digital technology has revolutionized the way most of the equipments work. Data is converted into binary code and then reassembled back into original form at reception point. Since these can be easily manipulated, it offers a wider range of options. Digital equipment is more expensive than analog equipment.

Comparison of Analog vs Digital Quality

Digital devices translate and reassemble data and in the process are more prone to loss of quality as compared to analog devices. Computer advancement has enabled use of error detection and error correction techniques to remove disturbances artificially from digital signals and improve quality.

Differences in Applications

Digital technology has been most efficient in cellular phone industry. Analog phones have become redundant even though sound clarity and quality was good.
Analog technology comprises of natural signals like human speech. With digital technology this human speech can be saved and stored in a computer. Thus digital technology opens up the horizon for endless possible uses.

Comparison chart


Analog

Digital

Signal Analog signal is a continuous signal which represents physical measurements. Digital signals are discrete time signals generated by digital modulation.
Waves Denoted by sine waves Denoted by square waves
Representation Uses continuous range of values to represent information Uses discrete or discontinuous values to represent information
Example Human voice in air, analog electronic devices. Computers, CDs, DVDs, and other digital electronic devices.
Technology Analog technology records waveforms as they are. Samples analog waveforms into a limited set of numbers and records them.
Data transmissions Subjected to deterioration by noise during transmission and write/read cycle. Can be noise-immune without deterioration during transmission and write/read cycle.
Response to Noise More likely to get affected reducing accuracy Less affected since noise response are analog in nature
Flexibility Analog hardware is not flexible. Digital hardware is flexible in implementation.
Uses Can be used in analog devices only. Best suited for audio and video transmission. Best suited for Computing and digital electronics.
Applications Thermometer PCs, PDAs
Bandwidth Analog signal processing can be done in real time and consumes less bandwidth. There is no guarantee that digital signal processing can be done in real time and consumes more bandwidth to carry out the same information.
Memory Stored in the form of wave signal Stored in the form of binary bit
Power Analog instrument draws large power Digital instrument drawS only negligible power
Cost Low cost and portable Cost is high and not easily portable
Impedance Low High order of 100 megaohm
Errors Analog instruments usually have a scale which is cramped at lower end and give considerable observational errors. Digital instruments are free from observational errors like parallax and approximation





திங்கள், 5 ஜனவரி, 2015

VPP VEE VSS VCC VDD

VPP: programming/erase voltage.
VEE: negative supply; FET's source (S)
VSS: or power cathode
VCC: power supply voltage (bipolar devices); power supply voltage (74 series digital circuits); voice carrier (VoiceControlledCarrier)
VDD: power supply voltage (unipolar devices); power supply voltage (4000 series digital circuits); drain voltage (FET)
VDD, VSS, VCC and VEE, VPP difference
Version 2:
Usually VCC and VDD power supply is, and VEE and VSS to negative, or the power supply.
VSS indicates that the connection to the scene effects tube-source (S) of power.
VDD represents a connection to the scene effects tube drain (D) of the power supply.
VEE indicates that the connection to the transistor emitter (E) the supply.
VCC represents a connection to the transistor collector (C) of the power supply.
They are named like this:
VCC and VEE, VDD, VSS is a chip, the decomposition of the power circuit, detailed rally point power polarity depends on device material. VCC generally refers to the direct connection to the integrated or decomposition circuit internal transistor C, VEE is connected to the integrated or decomposition circuit internal transistor's E-pole. Similarly, VDD, VSS is connected to an integrated internal, decomposition circuit FET of D and S. For example is using P Groove E/DMOS process of integration, then it should pick VDD power of negative and positive power VSS should receive.
Version 1:
1, the presence of effects tube (or COMS devices), VDD, VSS for drain as source, VDD and VSS refers to the symbol pin and does not represent a supply voltage.
2. some IC with VDD pin and the VCC PIN to demonstrate this device itself with voltage conversion function.
3, for digital circuits, VCC power supply voltage of the circuit, VDD is chip voltage (typically Vcc > Vdd), VSS is received.
II. Description
VSS: S = series represents the public connection, usually refers to the common grounding Terminal voltage circuits.
VCC: C = meaning of microcircuit circuit, namely, the access circuit voltage VDD: D = device represents the devices meant that the device's internal operating voltage;

What is the Difference Between Vcc, Vdd,Vss,Vee?

What is the Difference Between Vcc, Vdd,Vss,Vee?

Common supply terms has been blurred by the interchangeable application of TTL and CMOS logic families
But, the Fact is ,
Vcc and Vee are the terms used for Transistors .
Vdd and Vss are the terms used for FET’s
And in terms of supply voltages :
Vcc and Vdd is for positive supply.
Vee and Vss is for negetive supply.
Apparently this terminology originated in some way from the terminals of each type (i.e., Vcc is often applied to BJT collectors, Vee to BJT emitters, Vdd to FET drains, and Vss to FET sources). This notation then carries across to integrated circuits — TTL ICs were originally based on BJT technology, and so often use the Vcc / Vee terminology;
CMOS ICs are based on FET technology, and so often use the Vdd / Vss terminology.

What is Vcc, Vdd, Vss, Vee?

What is Vcc, Vdd, Vss, Vee?
These notations are used in describing voltages at various common power supply terminals (at these points, only a wire lead exists between the point and a power source) of a given circuit. It turns out that these common voltage terms map to transistor technology as follows:
BJT
FET
"Vxx" meaning
Vcc
Vdd
Positive supply voltage
Vee
Vss
Negative supply, ground

Apparently this terminology originated in some way from the terminals of each type of transistor, and their common connections in logic circuits (i.e., Vcc is often applied to BJT collectors, Vee to BJT emitters, Vdd to FET drains, and Vss to FET sources). This notation then carries across to integrated circuits -- TTL ICs were originally based on BJT technology, and so often use the Vcc / Vee terminology; CMOS ICs are based on FET technology, and so often use the Vdd / Vss terminology. The absolute distinctions between these common supply terms has since been blurred by the interchangeable application of TTL and CMOS logic families. Most CMOS (74HC / AC, etc.) IC data sheets now use Vcc and Gnd to designate the positive and negative supply pins.

வெள்ளி, 2 ஜனவரி, 2015

Combinational Logic Circuits

Combinational Logic Circuits

Unlike Sequential Logic Circuits whose outputs are dependant on both their present inputs and their previous output state giving them some form of Memory, the outputs of Combinational Logic Circuits are only determined by the logical function of their current input state, logic “0” or logic “1”, at any given instant in time.
The result is that combinational logic circuits have no feedback, and any changes to the signals being applied to their inputs will immediately have an effect at the output. In other words, in a Combinational Logic Circuit, the output is dependant at all times on the combination of its inputs. So if one of its inputs condition changes state, from 0-1 or 1-0, so too will the resulting output as by default combinational logic circuits have “no memory”, “timing” or “feedback loops” within their design.

Combinational Logic

combinational logic circuits
 
Combinational Logic Circuits are made up from basic logic NAND, NOR or NOT gates that are “combined” or connected together to produce more complicated switching circuits. These logic gates are the building blocks of Combinational Logic Circuits. An example of a combinational circuit is a decoder, which converts the binary code data present at its input into a number of different output lines, one at a time producing an equivalent decimal code at its output.
Combinational logic circuits can be very simple or very complicated and any combinational circuit can be implemented with only NAND and NOR gates as these are classed as “universal” gates.
The three main ways of specifying the function of a combinational logic circuit are:
  • 1. Boolean Algebra – This forms the algebraic expression showing the operation of the logic circuit for each input variable either True or False that results in a logic “1” output.
  • 2. Truth Table – A truth table defines the function of a logic gate by providing a concise list that shows all the output states in tabular form for each possible combination of input variable that the gate could encounter.
  • 3. Logic Diagram – This is a graphical representation of a logic circuit that shows the wiring and connections of each individual logic gate, represented by a specific graphical symbol, that implements the logic circuit.
and all three of these logic circuit representations are shown below.
combinational logic
 
As combinational logic circuits are made up from individual logic gates only, they can also be considered as “decision making circuits” and combinational logic is about combining logic gates together to process two or more signals in order to produce at least one output signal according to the logical function of each logic gate. Common combinational circuits made up from individual logic gates that carry out a desired application include Multiplexers, De-multiplexers, Encoders, Decoders, Full and Half Adders etc.

Classification of Combinational Logic

combination logic circuit
 
One of the most common uses of combinational logic is in Multiplexer and De-multiplexer type circuits. Here, multiple inputs or outputs are connected to a common signal line and logic gates are used to decode an address to select a single data input or output switch. A multiplexer consist of two separate components, a logic decoder and some solid state switches, but before we can discuss multiplexers, decoders and de-multiplexers in more detail we first need to understand how these devices use these “solid state switches” in their design.

Solid State Switches

Standard TTL logic devices made up from Transistors can only pass signal currents in one direction only making them “uni-directional” devices and poor imitations of conventional electro-mechanical switches or relays. However, some CMOS switching devices made up from FET’s act as near perfect “bi-directional” switches making them ideal for use as solid state switches.
Solid state switches come in a variety of different types and ratings, and there are many different applications for using solid state switches. They can basically be sub-divided into 3 different main groups for switching applications and in this combinational logic section we will only look at the Analogue type of switch but the principal is the same for all types including digital.

Solid State Switch Applications

  • • Analogue Switches – Used in Data Switching and Communications, Video and Audio Signal Switching, Instrumentation and Process Control Circuits …etc.
  • • Digital Switches – High Speed Data Transmission, Switching and Signal Routing, Ethernet, LAN’s, USB and Serial Transmissions …etc.
  • • Power Switches – Power Supplies and General “Standby Power” Switching Applications, Switching of Larger Voltages and Currents …etc.

Analogue Bilateral Switches

Analogue or “Analog” switches are those types that are used to switch data or signal currents when they are in their “ON” state and block them when they are in their “OFF” state. The rapid switching between the “ON” and the “OFF” state is usually controlled by a digital signal applied to the control gate of the switch. An ideal analogue switch has zero resistance when “ON” (or closed), and infinite resistance when “OFF” (or open) and switches with RON values of less than 1Ω are commonly available.

Solid State Analogue Switch

analogue switch
 
By connecting an N-channel MOSFET in parallel with a P-channel MOSFET allows signals to pass in either direction making it a Bi-directional switch and as to whether the N-channel or the P-channel device carries more signal current will depend upon the ratio between the input to the output voltage. The two MOSFET’s are switched “ON” or “OFF” by two internal non-inverting and inverting amplifiers.

Contact Types

Just like mechanical switches, analogue switches come in a variety of forms or contact types, depending on the number of “poles” and “throws” they offer. Thus, terms such as “SPST” (single-pole single throw) and “SPDT” (single-pole double-throw) also apply to solid state analogue switches with “make-before-break” and “break-before-make” configurations available.

Analogue Switch Types

analogue switch types
 
Individual analogue switches can be grouped together into standard IC packages to form devices with multiple switching configurations of SPST (single-pole single-throw) and SPDT (single-pole double-throw) as well as multi channel multiplexers. The most common and simplest analogue switch in a single IC package is the 74HC4066 which has 4 independent bi-directional “ON/OFF” Switches within a single package but the most widely used variants of the CMOS analogue switch are those described as “Multi-way Bilateral Switches” otherwise known as the “Multiplexer” and “De-multiplexer” IC´s and these are discussed in the next tutorial.

Combinational Logic Summary

Then to summarise, Combinational Logic Circuits consist of inputs, two or more basic logic gates and outputs. The logic gates are combined in such a way that the output state depends entirely on the input states. Combinational logic circuits have “no memory”, “timing” or “feedback loops”, there operation is instantaneous. A combinational logic circuit performs an operation assigned logically by a Boolean expression or truth table.
Examples of common Combinational Logic Circuits include: half adders, full adders, multiplexers, demultiplexers, encoders and decoders all of which we will look at in the next few tutorials

Some Common Applications of Logic Gates

Some Common Applications of Logic Gates


Application of OR gate

Wherever the occurrence of any one or more than one event is needed to be detected or some actions are to be taken after their occurrence, in all those cases OR gates can be used. It can be explained with an example. Suppose in an industrial plant if one or more than one parameter exceeds the safe value, some protective measure is needed to be done. In that case OR gate is used. We are going to show this with the help of a diagram.

Application of OR gate
Application of OR gate

The above figure is a typical schematic diagram where an OR gate is used to detect exceed of temperature or pressure and produce command signal for the system to take required actions.

Application of AND gate

There are mainly two applications of AND gate as Enable gate and Inhibit gate. Enable gate means allowance of data through a channel and Inhibit gate is just the reverse of that process i.e. disallowance of data through a channel. We are going to show an enabling operation to understand it in an easier way. Suppose in the measurement of frequency of a pulsed waveform. For measurement of frequency a gating pulse of known frequency is sent to enable the passage of the waveform whose frequency is to be measured. The diagram below shows the arrangement of the above explained operation.

Application of AND gate
Application of AND gate

Application of Ex-OR/Ex-NOR gate

These type of logic gates are used in generation of parity generation and checking units. The two diagrams below shows the even and odd parity generator circuits respectively for a four data.

Parity generation using Ex-OR/Ex-NOR gates
Parity generation using Ex-OR/Ex-NOR gates

With the help of these gates parity check operation can be also performed. The diagrams below show even and odd parity check.
Parity check using Ex-OR and Ex-NOR gates
Parity check using Ex-OR and Ex-NOR gates

Figure (a) shows the parity check using Ex-OR gates and the figure (b) shows the parity check using Ex-NOR gates.

Application of NOT gate or Inverters

NOT gates are also known as inverter because they invert the output given to them and show the reverse result. Now the CMOS inverters are commonly used to build square wave oscillators which are used for generating clock signals. The advantage of using these is they consume low power and their interfacing is very easy compared to other logic gates.

Square wave oscillator by using a ring configuration
Square wave oscillator by using a ring configuration

The above figure shows the most fundamental circuit made of ring configuration to generate square wave oscillator. The frequency of this type generator is given by
F\;=\;\frac{1}{2nt_p}{}
Where n represents the number of inverters and tp shows the propagation delay per gate.